Microvessels from Alzheimer's disease brains kill neurons in vitro.

  title={Microvessels from Alzheimer's disease brains kill neurons in vitro.},
  author={Paula Grammas and Pete W. Moore and Paul H. Weigel},
  journal={The American journal of pathology},
  volume={154 2},
Understanding the pathogenesis of Alzheimer's disease is of widespread interest because it is an increasingly prevalent disorder that is progressive, fatal, and currently untreatable. The dementia of Alzheimer's disease is caused by neuronal cell death. We demonstrate for the first time that blood vessels isolated from the brains of Alzheimer's disease patients can directly kill neurons in vitro. Either direct co-culture of Alzheimer's disease microvessels with neurons or incubation of cultured… CONTINUE READING
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