Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism.

@article{Antonucci2012MicrovesiclesRF,
  title={Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism.},
  author={Flavia Antonucci and Elena Turola and Loredana Riganti and Matteo Caleo and Martina Gabrielli and Cristiana Perrotta and Luisa Novellino and Emilio Clementi and Paola Giussani and Paola Viani and Michela Matteoli and Claudia Verderio},
  journal={The EMBO journal},
  year={2012},
  volume={31 5},
  pages={1231-40}
}
Microvesicles (MVs) released into the brain microenvironment are emerging as a novel way of cell-to-cell communication. We have recently shown that microglia, the immune cells of the brain, shed MVs upon activation but their possible role in microglia-to-neuron communication has never been explored. To investigate whether MVs affect neurotransmission, we analysed spontaneous release of glutamate in neurons exposed to MVs and found a dose-dependent increase in miniature excitatory postsynaptic… CONTINUE READING
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