Microvesicles derived from human bone marrow mesenchymal stem cells inhibit tumor growth.

  title={Microvesicles derived from human bone marrow mesenchymal stem cells inhibit tumor growth.},
  author={Stefania Bruno and Federica Collino and Maria Chiara Deregibus and Cristina Grange and Ciro Tetta and Giovanni Camussi},
  journal={Stem cells and development},
  volume={22 5},
Mesenchymal stem cells (MSCs) have opposite effects on tumor growth, being able either to favor angiogenesis and tumor initiation or to inhibit progression of established tumors. Factors produced by MSCs within the tumor microenvironment may be relevant for their biological effects. Recent studies demonstrated that microvesicles (MVs) are an integral component of inter-cellular communication within the tumor microenvironment. In the present study, we evaluated whether MVs derived from human… CONTINUE READING


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