Microvesicle-mediated RNA molecule delivery system using monocytes/macrophages.

  title={Microvesicle-mediated RNA molecule delivery system using monocytes/macrophages.},
  author={Yukihiro Akao and Akio Iio and Tomohiro Itoh and S Noguchi and Yuko Itoh and Yoshinori Ohtsuki and Tomoki Naoe},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  volume={19 2},
Microvesicles (MVs) and exosomes, which are shed from cells as a cell-to-cell communication tool, are possible vehicles for navigating RNA molecules to body tissues. It is considered that intravenous injection of such MVs or exosomes from patients would not cause severe not-self and toxic reactions. Previously, we found that macrophages take up liposome-entrapped RNA molecules, some of which remain undegraded in the cells. Here, we demonstrate that transfected RNA molecules in human monocytic… CONTINUE READING


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