Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection.

@article{Barnabas2019MicrovesiclePP,
  title={Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection.},
  author={Georgina D Barnabas and Keren Bahar-Shany and Stav Sapoznik and Limor Helpman and Yfat Kadan and Mario Beiner and Omer Weitzner and Nissim Arbib and Jacob Korach and Tamar Perri and Guy Katz and Anna Blecher and Benny Brandt and Edmund Friedman and David Stockheim and Ariella Jakobson-Setton and Ram Eitan and Shunit Armon and Hadar Brand and Oranit Zadok and Sarit Aviel-Ronen and Michal Harel and Tamar Geiger and Keren Levanon},
  journal={Molecular & cellular proteomics : MCP},
  year={2019},
  volume={18 5},
  pages={
          865-875
        }
}
High-grade ovarian cancer (HGOC) is the leading cause of mortality from gynecological malignancies, because of diagnosis at a metastatic stage. Current screening options fail to improve mortality because of the absence of early-stage-specific biomarkers. We postulated that a liquid biopsy, such as utero-tubal lavage (UtL), may identify localized lesions better than systemic approaches of serum/plasma analysis. Further, while mutation-based assays are challenged by the rarity of tumor DNA within… CONTINUE READING
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