Microvascular sites and characteristics of sickle cell adhesion to vascular endothelium in shear flow conditions: pathophysiological implications.

@article{Kaul1989MicrovascularSA,
  title={Microvascular sites and characteristics of sickle cell adhesion to vascular endothelium in shear flow conditions: pathophysiological implications.},
  author={Dhananjay K. Kaul and Mary E. Fabry and Ronald L. Nagel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 9},
  pages={3356-60}
}
To understand the role of sickle cell adherence to the vascular endothelium in the pathophysiology of sickle cell anemia (SS) vasoocclusion, we have carried out a microcirculatory study utilizing the ex vivo mesocecum vasculature of the rat. A single bolus of washed oxy-normal (AA) erythrocytes or oxy-SS cells (unseparated or density-defined SS cell classes) was infused. Hemodynamic monitoring and intravital microscopic observations of the microvascular flow revealed higher peripheral… CONTINUE READING

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