Microvascular responses to hemodilution with Hb vesicles as red blood cell substitutes: influence of O2 affinity.

@article{Sakai1999MicrovascularRT,
  title={Microvascular responses to hemodilution with Hb vesicles as red blood cell substitutes: influence of O2 affinity.},
  author={Hiromi Sakai and Adam Gilden Tsai and Ronald James Rohlfs and Hiroyuki Hara and Shinji Takeoka and Eihun Tsuchida and Marcos Intaglietta},
  journal={The American journal of physiology},
  year={1999},
  volume={276 2},
  pages={
          H553-62
        }
}
Phospholipid vesicles encapsulating purified hemoglobin (HbV) were developed to provide O2-carrying capacity to plasma expanders. Microvascular perfusion was determined for HbV with different O2 affinity (P50 = 9, 16, and 30 mmHg) prepared by coencapsulating pyridoxal 5'-phosphate (PLP) at the molar ratios of [PLP]/[Hb] = 0, 0.5, and 3, respectively (cf. hamster blood, P50: 28 mmHg), and suspended in 8 g/dl human serum albumin (HSA). Eighty percent of the red blood cell (RBC) mass of conscious… CONTINUE READING
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