Microvascular permeabilization and cardiomyocyte injury provoked by myocardial contrast echocardiography in a canine model.

@article{Miller2006MicrovascularPA,
  title={Microvascular permeabilization and cardiomyocyte injury provoked by myocardial contrast echocardiography in a canine model.},
  author={Douglas L. Miller and Edward M. Driscoll and Chunyan Dou and William F. Armstrong and Benedict Robert Lucchesi},
  journal={Journal of the American College of Cardiology},
  year={2006},
  volume={47 7},
  pages={1464-8}
}
OBJECTIVES The aim of this research was to evaluate the potential for myocardial contrast echocardiography (MCE) to provoke microscale bioeffects in a canine model. BACKGROUND Myocardial contrast echocardiography induces bioeffects in rat hearts, but translation of such results to larger animal models is uncertain. METHODS Dogs were anesthetized and prepared for open- (n = 22) or closed- (n = 6) chest MCE. Evans blue dye was injected intravenously as an indicator of microvascular leakage… CONTINUE READING