Microvascular permeability and number of tight junctions are modulated by cAMP.

@article{Adamson1998MicrovascularPA,
  title={Microvascular permeability and number of tight junctions are modulated by cAMP.},
  author={Roger H. Adamson and Bing Liu and G Nilson Fry and Lee L Rubin and Fitz-Roy Curry},
  journal={The American journal of physiology},
  year={1998},
  volume={274 6 Pt 2},
  pages={H1885-94}
}
We tested the hypothesis that increased endothelial cell adenosine 3',5'-cyclic monophosphate (cAMP) decreases microvascular permeability in vivo. The effects of cAMP-specific phosphodiesterase type IV inhibition and adenylate cyclase activation on microvascular hydraulic conductivity (Lp) were investigated in intact individual capillaries and postcapillary venules in mesentery of pithed frogs (Rana pipiens). Treatment with rolipram (10 microM) and forskolin (5 microM) for 25 min decreased Lp… CONTINUE READING

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