Microvascular oxygenation, oxidative stress, NO suppression and superoxide dismutase during postischemic reperfusion.

@article{Bertuglia2003MicrovascularOO,
  title={Microvascular oxygenation, oxidative stress, NO suppression and superoxide dismutase during postischemic reperfusion.},
  author={Silvia Bertuglia and Annamaria Giusti},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={285 3},
  pages={H1064-71}
}
Increased formation of reactive oxygen species (ROS) on reperfusion after ischemia underlies ischemia-reperfusion (I/R) damage. We measured, in real time, oxygen tension in both microvessels and tissue and oxidant stress during postischemic reperfusion in the hamster cheek pouch microcirculation. We measured Po2 by using phosphorescence quenching microscopy and ROS production in the systemic blood. We evaluated the effects of a nitric oxide synthase inhibitor (NG-monomethyl-L-arginine, L-NMMA… CONTINUE READING

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