Microvascular network remodeling in dura mater of ovariectomized pigs: role for angiopoietin-1 in estrogen-dependent control of vascular stability.

@article{Glinskii2007MicrovascularNR,
  title={Microvascular network remodeling in dura mater of ovariectomized pigs: role for angiopoietin-1 in estrogen-dependent control of vascular stability.},
  author={Olga V. Glinskii and Tsghe W Abraha and James R. Turk and Leona J. Rubin and Virginia H. Huxley and Vladislav V. Glinsky},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={293 2},
  pages={H1131-7}
}
Estrogen is a key regulator of vascular responses and angioadaptation in multiple organs and tissues, including brain. However, the consequences of a loss of ovarian steroid hormone secretion on the status of microvascular networks in brain and meninges are largely unknown. Here, using the perfused dura mater model coupled with high-resolution digital epifluorescence and laser scanning confocal microscopy and computer-assisted morphometric analysis, we demonstrate that cessation of ovarian… CONTINUE READING

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