Microvascular disease: what does the UKPDS tell us about diabetic nephropathy?

  title={Microvascular disease: what does the UKPDS tell us about diabetic nephropathy?},
  author={Rudy W. Bilous},
  journal={Diabetic medicine : a journal of the British Diabetic Association},
  volume={25 Suppl 2},
The UK Prospective Diabetes Study is the largest study in Type 2 diabetes with pre-specified renal outcomes. The study showed that the natural history of nephropathy in newly diagnosed Type 2 diabetic patients was similar to that described previously in those with Type 1 diabetes. Around 2% per annum progress from normo- to micro-albuminuria [urinary albumin concentration (UAC) > 50 mg/l] and a further 2% from microalbuminuria to clinical grade proteinuria (UAC > 300 mg/l). Mortality rates for… CONTINUE READING


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