Microvascular deposition of complement membrane attack complex in dermatomyositis.

  title={Microvascular deposition of complement membrane attack complex in dermatomyositis.},
  author={John T. Kissel and Jerry R. Mendell and Kottil W. Rammohan},
  journal={The New England journal of medicine},
  volume={314 6},
We examined the role of the complement system in the pathogenesis of dermatomyositis. Using an antibody against the neoantigens of the terminal C5b-9 membrane attack complex, we performed immunocytochemical studies that localized this complex to the intramuscular microvasculature (arterioles and capillaries) of muscle biopsy specimens from 10 of 12 patients (83 percent) with childhood dermatomyositis and 5 of 19 patients (26 percent) with adult dermatomyositis. Fifty-two control specimens… CONTINUE READING


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