Microvascular brain damage with aging and hypertension: pathophysiological consideration and clinical implications.

@article{Scuteri2011MicrovascularBD,
  title={Microvascular brain damage with aging and hypertension: pathophysiological consideration and clinical implications.},
  author={Angelo Scuteri and Peter Nilsson and Christopher Tzourio and Josep Redon and St{\'e}phane Laurent},
  journal={Journal of hypertension},
  year={2011},
  volume={29 8},
  pages={1469-77}
}
Loss of cognitive function and hypertension are two common conditions in the elderly and both significantly contribute to loss of personal independency. Microvascular brain damage - the result of age-associated alteration in large arteries and the progressive mismatch of their cross-talk with small cerebral arteries - represents a potent risk factor for cognitive decline and for the onset of dementia in older individuals. The present review discusses the complexity of factors linking large… CONTINUE READING

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Age, neuropathology, and dementia.

The New England journal of medicine • 2009

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