Microvascular NADPH oxidase in health and disease.

@article{Li2017MicrovascularNO,
  title={Microvascular NADPH oxidase in health and disease.},
  author={Yao Dong Li and Patrick J Pagano},
  journal={Free radical biology & medicine},
  year={2017},
  volume={109},
  pages={
          33-47
        }
}
The systemic and cerebral microcirculation contribute critically to regulation of local and global blood flow and perfusion pressure. Microvascular dysfunction, commonly seen in numerous cardiovascular pathologies, is associated with alterations in the oxidative environment including potentiated production of reactive oxygen species (ROS) and subsequent activation of redox signaling pathways. NADPH oxidases (Noxs) are a primary source of ROS in the vascular system and play a central role in… CONTINUE READING
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