Microtubules that form the stationary lattice of muscle fibers are dynamic and nucleated at Golgi elements

@inproceedings{Oddoux2013MicrotubulesTF,
  title={Microtubules that form the stationary lattice of muscle fibers are dynamic and nucleated at Golgi elements},
  author={Sarah Oddoux and Kristien J Zaal and Victoria V Tate and Aster Kenea and Shuktika A. Nandkeolyar and Ericka Reid and Wenhua Liu and Evelyn Ralston},
  booktitle={The Journal of cell biology},
  year={2013}
}
Skeletal muscle microtubules (MTs) form a nonclassic grid-like network, which has so far been documented in static images only. We have now observed and analyzed dynamics of GFP constructs of MT and Golgi markers in single live fibers and in the whole mouse muscle in vivo. Using confocal, intravital, and superresolution microscopy, we find that muscle MTs are dynamic, growing at the typical speed of ∼9 µm/min, and forming small bundles that build a durable network. We also show that static… CONTINUE READING

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