Microtubules provide directional information for core PCP function

@inproceedings{Matis2014MicrotubulesPD,
  title={Microtubules provide directional information for core PCP function},
  author={Maja Matis and David A Russler-Germain and Qie Hu and Claire Jennifer Tomlin and Jeffrey D. Axelrod},
  booktitle={eLife},
  year={2014}
}
Planar cell polarity (PCP) signaling controls the polarization of cells within the plane of an epithelium. Two molecular modules composed of Fat(Ft)/Dachsous(Ds)/Four-jointed(Fj) and a 'PCP-core' including Frizzled(Fz) and Dishevelled(Dsh) contribute to polarization of individual cells. How polarity is globally coordinated with tissue axes is unresolved. Consistent with previous results, we find that the Ft/Ds/Fj-module has an effect on a MT-cytoskeleton. Here, we provide evidence for the model… CONTINUE READING
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polarity phenotype by altering frizzled signaling

  • B Aigouy, R Farhadifar, +4 authors S. Eaton
  • 2010
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