Microtubules provide directional cues for polarized axonal transport through interaction with kinesin motor head

@article{Nakata2003MicrotubulesPD,
  title={Microtubules provide directional cues for polarized axonal transport through interaction with kinesin motor head},
  author={Takao Nakata and Nobutaka Hirokawa},
  journal={The Journal of Cell Biology},
  year={2003},
  volume={162},
  pages={1045 - 1055}
}
Post-Golgi carriers of various newly synthesized axonal membrane proteins, which possess kinesin (KIF5)-driven highly processive motility, were transported from the TGN directly to axons. We found that KIF5 has a preference to the microtubules in the initial segment of axon. Low dose paclitaxel treatment caused missorting of KIF5, as well as axonal membrane proteins to the tips of dendrites. Microtubules in the initial segment of axons showed a remarkably high affinity to EB1-YFP, which was… CONTINUE READING
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