Microtubules-interfering agents restrict aryl hydrocarbon receptor-mediated CYP1A2 induction in primary cultures of human hepatocytes via c-jun-N-terminal kinase and glucocorticoid receptor.

@article{Vrzal2008MicrotubulesinterferingAR,
  title={Microtubules-interfering agents restrict aryl hydrocarbon receptor-mediated CYP1A2 induction in primary cultures of human hepatocytes via c-jun-N-terminal kinase and glucocorticoid receptor.},
  author={Radim Vrzal and Martine Daujat-Chavanieu and Jean Marc Pascussi and Jitka Ulrichov{\'a} and Patrick Maurel and Zdenek Dvorak},
  journal={European journal of pharmacology},
  year={2008},
  volume={581 3},
  pages={244-54}
}
Disruption of microtubules has been shown to cause suppression of inducibility of major cytochromes P450 (CYP) through several nuclear receptors. Here we tested the effects of structurally different clinically used microtubules-interfering agents (MIAs), such as colchicine, vincristine, vinblastine, nocodazole and taxol on aryl hydrocarbon receptor signaling pathway in human hepatocytes. We show that tested MIAs inhibit 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible expression of CYP1A2… CONTINUE READING