Microtubules as a target for anticancer drugs

@article{Jordan2004MicrotubulesAA,
  title={Microtubules as a target for anticancer drugs},
  author={Mary Ann Jordan and Leslie Wilson},
  journal={Nature Reviews Cancer},
  year={2004},
  volume={4},
  pages={253-265}
}
Highly dynamic mitotic-spindle microtubules are among the most successful targets for anticancer therapy. Microtubule-targeted drugs, including paclitaxel and Vinca alkaloids, were previously considered to work primarily by increasing or decreasing the cellular microtubule mass. Although these effects might have a role in their chemotherapeutic actions, we now know that at lower concentrations, microtubule-targeted drugs can suppress microtubule dynamics without changing microtubule mass; this… 
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