Microtubules as a target for anticancer drugs

  title={Microtubules as a target for anticancer drugs},
  author={M. Jordan and L. Wilson},
  journal={Nature Reviews Cancer},
  • M. Jordan, L. Wilson
  • Published 2004
  • Biology, Medicine
  • Nature Reviews Cancer
  • Highly dynamic mitotic-spindle microtubules are among the most successful targets for anticancer therapy. Microtubule-targeted drugs, including paclitaxel and Vinca alkaloids, were previously considered to work primarily by increasing or decreasing the cellular microtubule mass. Although these effects might have a role in their chemotherapeutic actions, we now know that at lower concentrations, microtubule-targeted drugs can suppress microtubule dynamics without changing microtubule mass; this… CONTINUE READING
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