Microtubules as a target for anticancer drugs
@article{Jordan2004MicrotubulesAA, title={Microtubules as a target for anticancer drugs}, author={Mary Ann Jordan and Leslie Wilson}, journal={Nature Reviews Cancer}, year={2004}, volume={4}, pages={253-265} }
Highly dynamic mitotic-spindle microtubules are among the most successful targets for anticancer therapy. Microtubule-targeted drugs, including paclitaxel and Vinca alkaloids, were previously considered to work primarily by increasing or decreasing the cellular microtubule mass. Although these effects might have a role in their chemotherapeutic actions, we now know that at lower concentrations, microtubule-targeted drugs can suppress microtubule dynamics without changing microtubule mass; this…
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