Microtubules are stabilized in confluent epithelial cells but not in fibroblasts

@article{Pepperkok1990MicrotubulesAS,
  title={Microtubules are stabilized in confluent epithelial cells but not in fibroblasts},
  author={Rainer Pepperkok and M. H. Br{\'e} and J Davoust and Thomas E. Kreis},
  journal={The Journal of Cell Biology},
  year={1990},
  volume={111},
  pages={3003 - 3012}
}
Rhodamine-tagged tubulin was microinjected into epithelial cells (MDCK) and fibroblasts (Vero) to characterize the dynamic properties of labeled microtubules in sparse and confluent cells. Fringe pattern fluorescence photobleaching revealed two components with distinct dynamic properties. About one-third of the injected tubulin diffused rapidly in the cytoplasm with a diffusion coefficient of 1.3-1.6 x 10(-8) cm2/s. This pool of soluble cytoplasmic tubulin was increased to greater than 80% when… CONTINUE READING

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