Microtubules are involved in glucose-dependent dissociation of the yeast vacuolar [H+]-ATPase in vivo.

@article{Xu2001MicrotubulesAI,
  title={Microtubules are involved in glucose-dependent dissociation of the yeast vacuolar [H+]-ATPase in vivo.},
  author={Tao Xu and Michael Forgac},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 27},
  pages={24855-61}
}
The vacuolar [H(+)]-ATPases (V-ATPases) are composed of a peripheral V(1) domain and a membrane-embedded V(0) domain. Reversible dissociation of the V(1) and V(0) domains has been observed in both yeast and insects and has been suggested to represent a general regulatory mechanism for controlling V-ATPase activity in vivo. In yeast, dissociation of the V-ATPase is triggered by glucose depletion, but the signaling pathways that connect V-ATPase dissociation and glucose metabolism have not been… CONTINUE READING