Microtubules are associated with intracellular movement and spread of the periodontopathogen Actinobacillus actinomycetemcomitans.

@article{Meyer1999MicrotubulesAA,
  title={Microtubules are associated with intracellular movement and spread of the periodontopathogen Actinobacillus actinomycetemcomitans.},
  author={Diane H. Meyer and John E Rose and Julian Lippmann and PAULA M. FIVES-TAYLOR},
  journal={Infection and immunity},
  year={1999},
  volume={67 12},
  pages={6518-25}
}
Actinobacillus actinomycetemcomitans SUNY 465, the invasion prototype strain, enters epithelial cells by an actin-dependent mechanism, escapes from the host cell vacuole, and spreads intracellularly and to adjacent epithelial cells via intercellular protrusions. Internalized organisms also egress from host cells into the assay medium via protrusions that are associated with just a single epithelial cell. Here we demonstrate that agents which inhibit microtubule polymerization (e.g., colchicine… CONTINUE READING

6 Figures & Tables

Connections & Topics

Mentioned Connections BETA
Here we demonstrate that agents which inhibit microtubule polymerization ( e.g. , colchicine ) and those which stabilize polymerized microtubules ( e.g. , taxol ) both increase markedly the number of intracellular A. actinomycetemcomitans organisms .
Furthermore , both colchicine and taxol prevented the egression of A. actinomycetemcomitans from host cells into the assay medium .
Furthermore , both colchicine and taxol prevented the egression of A. actinomycetemcomitans from host cells into the assay medium .
Here we demonstrate that agents which inhibit microtubule polymerization ( e.g. , colchicine ) and those which stabilize polymerized microtubules ( e.g. , taxol ) both increase markedly the number of intracellular A. actinomycetemcomitans organisms .
All Topics