Microtubules and resistance to tubulin-binding agents

  title={Microtubules and resistance to tubulin-binding agents},
  author={Maria Kavallaris},
  journal={Nature Reviews Cancer},
Microtubules are dynamic structures composed of α–β-tubulin heterodimers that are essential in cell division and are important targets for cancer drugs. Mutations in β-tubulin that affect microtubule polymer mass and/or drug binding are associated with resistance to tubulin-binding agents such as paclitaxel. The aberrant expression of specific β-tubulin isotypes, in particular βIII-tubulin, or of microtubule-regulating proteins is important clinically in tumour aggressiveness and resistance to… CONTINUE READING
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