Microtubules and Their Role in Cellular Stress in Cancer

  title={Microtubules and Their Role in Cellular Stress in Cancer},
  author={Amelia L. Parker and Maria Kavallaris and Joshua Mccarroll},
  booktitle={Front. Oncol.},
Microtubules are highly dynamic structures, which consist of α- and β-tubulin heterodimers, and are involved in cell movement, intracellular trafficking, and mitosis. In the context of cancer, the tubulin family of proteins is recognized as the target of the tubulin-binding chemotherapeutics, which suppress the dynamics of the mitotic spindle to cause mitotic arrest and cell death. Importantly, changes in microtubule stability and the expression of different tubulin isotypes as well as altered… CONTINUE READING
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