Microtubule-targeting anticancer agents from marine natural substance.

  title={Microtubule-targeting anticancer agents from marine natural substance.},
  author={Zhiguo Liu and Pengfei Xu and Tao Wu and Wenbin Zeng},
  journal={Anti-cancer agents in medicinal chemistry},
  volume={14 3},
Effective novel therapeutics is urgently needed due to increasing incidence of malignant cancer and drug multi-resistance. Natural products and their derivatives have historically been a source of pharmaceutical leads and therapeutic drugs. Microtubule-targeting compounds are among the most promising candidates in the combat against cancer. In particular, marine natural products (MNPs) have demonstrated exceptional potency and potential as anticancer agents. Drug discovery from MNPs provides a… CONTINUE READING