Microtubule-targeting agents can sensitize cancer cells to ionizing radiation by an interphase-based mechanism

Abstract

Background The cytotoxic effects of microtubule-targeting agents (MTAs) are often attributed to targeted effects on mitotic cells. In clinical practice, MTAs are combined with DNA-damaging agents such as ionizing radiation (IR) with the rationale that mitotic cells are highly sensitive to DNA damage. In contrast, recent studies suggest that MTAs synergize… (More)
DOI: 10.2147/OTT.S143096

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