Microtubule stabilization specifies initial neuronal polarization

@article{Witte2008MicrotubuleSS,
  title={Microtubule stabilization specifies initial neuronal polarization},
  author={Harald Witte and Dorothee Neukirchen and Frank Bradke},
  journal={The Journal of Cell Biology},
  year={2008},
  volume={180},
  pages={619 - 632}
}
Axon formation is the initial step in establishing neuronal polarity. We examine here the role of microtubule dynamics in neuronal polarization using hippocampal neurons in culture. We see increased microtubule stability along the shaft in a single neurite before axon formation and in the axon of morphologically polarized cells. Loss of polarity or formation of multiple axons after manipulation of neuronal polarity regulators, synapses of amphids defective (SAD) kinases, and glycogen synthase… CONTINUE READING
Highly Influential
This paper has highly influenced 25 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
201 Citations
53 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 201 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 53 references

Similar Papers

Loading similar papers…