Microtubule stabilization by taxol inhibits initiation of DNA synthesis by thrombin and by epidermal growth factor.

@article{Crossin1981MicrotubuleSB,
  title={Microtubule stabilization by taxol inhibits initiation of DNA synthesis by thrombin and by epidermal growth factor.},
  author={Kathryn L Crossin and Darrell H. Carney},
  journal={Cell},
  year={1981},
  volume={27 2 Pt 1},
  pages={341-50}
}
Several observations have suggested that microtubule depolymerization might act as a regulator of cell proliferation. To determine whether microtubule depolymerization is required for growth-factor-induced initiation of DNA synthesis, we treated serum-free cultures of mouse embryo cells with taxol to stabilize their microtubules and measured the initiation of DNA synthesis by thrombin and epidermal growth factor (EGF). Pretreatment of quiescent cultures of mouse embryo cells with 10 microgram… CONTINUE READING

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