Microtubule stability studied by three-dimensional molecular theory of solvation.

@article{Drabik2007MicrotubuleSS,
  title={Microtubule stability studied by three-dimensional molecular theory of solvation.},
  author={Piotr Drabik and Sergey Gusarov and Andriy Kovalenko},
  journal={Biophysical journal},
  year={2007},
  volume={92 2},
  pages={
          394-403
        }
}
We study microtubular supramolecular architectures of tubulin dimers self-assembling into linear protofilaments, in turn forming a closed tube, which is an important component of the cytoskeleton. We identify the protofilament arrangements with the lowest free energy using molecular dynamics to optimize tubulin conformations. We then use the three-dimensional molecular theory of solvation to obtain the hydration structure of protofilaments built of optimized tubulins and the solvent-mediated… CONTINUE READING

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CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 87 REFERENCES

The physical basis of microtubule structure and stability.

  • Protein science : a publication of the Protein Society
  • 2003
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Effects of microgravity on cell cytoskeleton and embryogenesis.

  • The International journal of developmental biology
  • 2006
VIEW 3 EXCERPTS

Information processing in brain microtubules

J. Faber, R. Portugala, L. P. Rosa
  • 2006
VIEW 2 EXCERPTS

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