Microtubule stability, Golgi organization, and transport flux require dystonin-a2–MAP1B interaction

@inproceedings{Ryan2012MicrotubuleSG,
  title={Microtubule stability, Golgi organization, and transport flux require dystonin-a2–MAP1B interaction},
  author={Scott D. Ryan and Kunal Bhanot and Andrew Ferrier and Yves de Repentigny and Alphonse Chu and Alexandre Blais and Rashmi Kothary},
  booktitle={The Journal of cell biology},
  year={2012}
}
Loss of function of dystonin cytoskeletal linker proteins causes neurodegeneration in dystonia musculorum (dt) mutant mice. Although much investigation has focused on understanding dt pathology, the diverse cellular functions of dystonin isoforms remain poorly characterized. In this paper, we highlight novel functions of the dystonin-a2 isoform in mediating microtubule (MT) stability, Golgi organization, and flux through the secretory pathway. Using dystonin mutant mice combined with isoform… CONTINUE READING