Microtubule-severing protein Katanin regulates neuromuscular junction development and dendritic elaboration in Drosophila.

@article{Mao2014MicrotubuleseveringPK,
  title={Microtubule-severing protein Katanin regulates neuromuscular junction development and dendritic elaboration in Drosophila.},
  author={Chuan-Xi Mao and Ying Xiong and Zhaohuan Xiong and Qifu Wang and Yong qun Zhang and Shan Jin},
  journal={Development},
  year={2014},
  volume={141 5},
  pages={1064-74}
}
Microtubules (MTs) are crucial for diverse biological processes including cell division, cell growth and motility, intracellular transport and the maintenance of cell shape. MT abnormalities are associated with neurodevelopmental and neurodegenerative diseases such as hereditary spastic paraplegia. Among many MT regulators, katanin was the first identified MT-severing protein, but its neuronal functions have not yet been examined in a multicellular organism. Katanin consists of two subunits… CONTINUE READING
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