Microtubule-severing enzymes at the cutting edge.

@article{Sharp2012MicrotubuleseveringEA,
  title={Microtubule-severing enzymes at the cutting edge.},
  author={David J. Sharp and Jennifer L. Ross},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 11},
  pages={
          2561-9
        }
}
ATP-dependent severing of microtubules was first reported in Xenopus laevis egg extracts in 1991. Two years later this observation led to the purification of the first known microtubule-severing enzyme, katanin. Katanin homologs have now been identified throughout the animal kingdom and in plants. Moreover, members of two closely related enzyme subfamilies, spastin and fidgetin, have been found to sever microtubules and might act alongside katanins in some contexts (Roll-Mecak and McNally, 2010… CONTINUE READING

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 65 CITATIONS

Building the Neuronal Microtubule Cytoskeleton

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Anaphase A: Disassembling Microtubules Move Chromosomes toward Spindle Poles

  • Biology
  • 2017
VIEW 11 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Anaphase A: Melting Microtubules Move Chromosomes toward Spindle Poles

VIEW 12 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Fidgetin regulates cultured astrocyte migration by severing tyrosinated microtubules at the leading edge

  • Molecular biology of the cell
  • 2017
VIEW 3 EXCERPTS
CITES RESULTS & BACKGROUND

FILTER CITATIONS BY YEAR

2011
2019

CITATION STATISTICS

  • 4 Highly Influenced Citations

  • Averaged 8 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 89 REFERENCES

Acetylation of microtubules influences their sensitivity to severing by katanin in neurons and fibroblasts.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2010
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…