Microtubule polymerization dynamics.

  title={Microtubule polymerization dynamics.},
  author={Arshad Desai and Timothy J. Mitchison},
  journal={Annual review of cell and developmental biology},
The polymerization dynamics of microtubules are central to their biological functions. Polymerization dynamics allow microtubules to adopt spatial arrangements that can change rapidly in response to cellular needs and, in some cases, to perform mechanical work. Microtubules utilize the energy of GTP hydrolysis to fuel a unique polymerization mechanism termed dynamic instability. In this review, we first describe progress toward understanding the mechanism of dynamic instability of pure tubulin… 

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