Microtubule length dependence of motor traffic in cells

  title={Microtubule length dependence of motor traffic in cells},
  author={Yunxin Zhang},
  journal={The European Physical Journal E},
  • Yunxin Zhang
  • Published 18 May 2012
  • Biology, Computer Science
  • The European Physical Journal E
Motor proteins in living cells, such as kinesin and dynein, can move processively along the microtubule (MT), and can also detach from or attach to MT stochastically. Experiments found that the traffic of motors along MT may be jammed; thus various theoretical models were designed to understand this process. However, previous studies mainly focused on motor attachment/detachment rate dependent properties. Leduc et al. recently found that the traffic jam of motor protein Kip3 depends on MT… 
Theoretical Analysis of Kinesin KIF1A Transport Along Microtubule
Recently, a three-state model is presented to describe the intracellular traffic of unconventional (single-headed) kinesin KIF1A (Phys. Rev. Lett. 95:118101, 2005), in which each motor can bind
Mean-field analysis of two-species TASEP with attachment and detachment
TASEP with two particle species is discussed in this study and it is shown that domain wall and boundary layer of single species densities always appear simultaneously with those of the total particle density.
A stochastic model that explains axonal organelle pileups induced by a reduction of molecular motors
Simulation results of the model support the hypothesis of the underlying mechanism of local axonal cargo accumulation induced by a global reduction of functional molecular motors in axons, and identify key questions that must be tested experimentally.
Dynamics of Intracellular Nano-Transport by Kinesins
A new physicsba ed mathematical model of kinesin is developed to capture the long range transport and the binding of obstacles such as tau proteins on the track are considered by using the chemical kinetics between tau pr oteins and the tracks.
Navigating the cell: how motors overcome roadblocks and traffic jams to efficiently transport cargo.
This perspective summarizes the challenges that motors face in navigating the complex cytoskeleton and the lessons learned about transport in crowded environments from both bottom-up in vitro studies as well as top-down in vivo studies.
Mean-field analysis of two-species totally asymmetric simple exclusion process (TASEP) with attachment and detachment
In the field of statistical physics, unidirectional motion of a large number of particles along a single track can be described by totally asymmetric simple exclusion process (TASEP), from which many
Relationship between promoter sequence and its strength in gene expression
A theoretical model is presented to describe the relationship between promoter strength and nucleotide sequence and shows that promoter strength is greatly influenced by nucleotide groups with three adjacent nucleotides in their sequences.
Dynamics in multi-lane TASEPs coupled with asymmetric lane-changing rates
The paper studies periodic two-dimensional exclusion processes constituted by multi-lane totally asymmetric simple exclusion processes with the effect of asymmetric lane-changing rates. Particles in
Dynamics in phase transitions of TASEP coupled with multi-lane SEPs
In this paper, we study a traffic model constituted by totally asymmetric simple exclusion process (TASEP) and two-lane simple exclusion processes (SEP). Then we generalize it to study TASEP coupled


Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors
A tug-of-war mechanism based on molecular motors that pull cargos along cytoskeletal filaments is found to be highly cooperative and to exhibit seven different motility regimes depending on the precise values of the single motor parameters.
Molecular motors methods and protocols
This work has shown that Kinesin-related Motor Proteins During Spermatogenesis and Chemical-Genetic Inhibition of Sensitized Mutant Unconventional Myosins, as well as in Vitro and In Vivo Analysis of Microtubule Destabilizing Kinesins, are regulated by Calcium/Calmodulin Regulation and ATPase Assays.
Effects of the chemomechanical stepping cycle on the traffic of molecular motors.
We discuss effects of the stepping kinetics of molecular motors on their traffic behavior on crowded filaments using a simple two-state chemomechanical cycle. While the general traffic behavior is
Cell Movements: From Molecules to Motility
1. Cell Swimming 2. Migration of Cells over Surfaces 3. Cell Behavior 4. The Cytoskeleton 5. Actin Filaments 6. Actin and Membranes 7. Myosin 8. Firoblast Locomotion 9. The Molecular Basis of Muscle
Mechanics of Motor Proteins and the Cytoskeleton
The Motility Models: From Crossbridges to Motion chapter describes the building blocks of the Cytoskeleton and some of the mechanisms used in its manufacture are described.