Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase

  title={Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase},
  author={Ellen J Ezratty and Michael A. Partridge and Gregg G. Gundersen},
  journal={Nature Cell Biology},
Imaging studies implicate microtubule targeting of focal adhesions in focal adhesion disassembly, although the molecular mechanism is unknown. Here, we develop a model system of focal adhesion disassembly based on the finding that microtubule regrowth after nocodazole washout induces disassembly of focal adhesions, and that this disassembly occurs independently of Rho and Rac, but depends on focal adhesion kinase (FAK) and dynamin. During disassembly, dynamin interacts with FAK and colocalizes… 

Focal adhesion disassembly requires clathrin‐dependent endocytosis of integrins

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Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions

C cortical microtubule stabilization sites containing CLASPs, KIF21A, LL5P and liprins are recruited to focal adhesions by the adaptor protein KANK1, which directly interacts with the major adhesion component, talin.

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FAK–Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly

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mDia mediates Rho-regulated formation and orientation of stable microtubules

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