Microtubule guidance tested through controlled cell geometry.

Abstract

In moving cells dynamic microtubules (MTs) target and disassemble substrate adhesion sites (focal adhesions; FAs) in a process that enables the cell to detach from the substrate and propel itself forward. The short-range interactions between FAs and MT plus ends have been observed in several experimental systems, but the spatial overlap of these structures… (More)
DOI: 10.1242/jcs.110494

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