Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts

@article{WatermanStorer1999MicrotubuleGA,
  title={Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts},
  author={Clare M. Waterman-Storer and Rebecca A. Worthylake and Betty P. Liu and Keith Burridge and Edward D. Salmon},
  journal={Nature Cell Biology},
  year={1999},
  volume={1},
  pages={45-50}
}
Microtubules are involved in actin-based protrusion at the leading-edge lamellipodia of migrating fibroblasts. Here we show that the growth of microtubules induced in fibroblasts by removal of the microtubule destabilizer nocodazole activates Rac1 GTPase, leading to the polymerization of actin in lamellipodial protrusions. Lamellipodial protrusions are also activated by the rapid growth of a disorganized array of very short microtubules induced by the microtubule-stabilizing drug taxol. Thus… Expand
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