Microtubule dysfunction precedes transport impairment and mitochondria damage in MPP+ -induced neurodegeneration.

@article{Cartelli2010MicrotubuleDP,
  title={Microtubule dysfunction precedes transport impairment and mitochondria damage in MPP+ -induced neurodegeneration.},
  author={Daniele Cartelli and Cristina L Ronchi and Maria Grazia Maggioni and Simona Rodighiero and Erminio Giavini and Graziella Cappelletti},
  journal={Journal of neurochemistry},
  year={2010},
  volume={115 1},
  pages={
          247-58
        }
}
Dysfunction of the microtubule (MT) system is an emerging theme in the pathogenesis of Parkinson's disease. This study was designed to investigate the putative role of MT dysfunction in dopaminergic neuron death induced by the neurotoxin 1-methyl-4-phenylpiridinium (MPP(+)). In nerve growth factor-differentiated PC12 cells, we have analyzed post-translational modifications of tubulin known to be associated with differently dynamic MTs and show that MPP(+) causes a selective loss of dynamic MTs… CONTINUE READING
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