Microtubule dynamics as a target in oncology.

  title={Microtubule dynamics as a target in oncology.},
  author={April L Risinger and Francis J Giles and Susan L. Mooberry},
  journal={Cancer treatment reviews},
  volume={35 3},
Drugs that affect microtubule dynamics, including the taxanes and vinca alkaloids, have been a mainstay in the treatment of leukemias and solid tumors for decades. New, more effective microtubule-targeting agents continue to enter into clinical trials and some, including the epothilone ixapebilone, have been approved for use. In contrast, several other drugs of this class with promising preclinical data were later shown to be ineffective or intolerable in animal models or clinical trials. In… CONTINUE READING
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