Microtubule dynamic instability: numerical simulation of microtubule transition properties using a Lateral Cap model.

@article{Bayley1990MicrotubuleDI,
  title={Microtubule dynamic instability: numerical simulation of microtubule transition properties using a Lateral Cap model.},
  author={Peter M. Bayley and Maria J. Schilstra and Stephen R. Martin},
  journal={Journal of cell science},
  year={1990},
  volume={95 ( Pt 1)},
  pages={33-48}
}
We present a numerical formulation for the dynamic instability of microtubules involving the stabilisation of growing microtubules by a single layer of tubulin-GTP, with GTP hydrolysis effectively coupled to tubulin-GTP addition. This Lateral Cap model provides a readily visualised, working mechanism for the co-existence and interconversion of growing and shrinking microtubules. This class of model is specified in terms of a hydrolysis rule, whereby the addition of tubulin-GTP causes hydrolysis… CONTINUE READING
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