Microtubule drugs: action, selectivity, and resistance across the kingdoms of life

@article{Dostl2014MicrotubuleDA,
  title={Microtubule drugs: action, selectivity, and resistance across the kingdoms of life},
  author={V{\'i}t Dost{\'a}l and Lenka Libusov{\'a}},
  journal={Protoplasma},
  year={2014},
  volume={251},
  pages={991-1005}
}
Microtubule drugs such as paclitaxel, colchicine, vinblastine, trifluralin, or oryzalin form a chemically diverse group that has been reinforced by a large number of novel compounds over time. They all share the ability to change microtubule properties. The profound effects of disrupted microtubule systems on cell physiology can be used in research as well as anticancer treatment and agricultural weed control. The activity of microtubule drugs generally depends on their binding to α- and… CONTINUE READING

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