Microtubule disruption and tumor suppression by mitogen-activated protein kinase phosphatase 4.

@article{Liu2007MicrotubuleDA,
  title={Microtubule disruption and tumor suppression by mitogen-activated protein kinase phosphatase 4.},
  author={Yuangang Liu and James P Lagowski and Aaron Joseph Sundholm and Alexandra Appelgren Sundberg and Molly Kulesz-Martin},
  journal={Cancer research},
  year={2007},
  volume={67 22},
  pages={
          10711-9
        }
}
The extracellular signal-regulated kinase (Erk) is one of the downstream effectors of the Ras pathway whose activation is essential for the proliferation and survival of cancer cells. Erk activation is negatively regulated by mitogen-activated protein kinase (MAPK) phosphatases (MKP), which are generally up-regulated by Erk activation, thus forming a feedback loop for regulation of Erk activity. In searching for early alterations in the Ras pathway in epidermal carcinogenesis, we identified… CONTINUE READING

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