Microtubule-disrupting agents inhibit nitric oxide production in murine peritoneal macrophages stimulated with lipopolysaccharide or paclitaxel (Taxol).

@article{Kirikae1996MicrotubuledisruptingAI,
  title={Microtubule-disrupting agents inhibit nitric oxide production in murine peritoneal macrophages stimulated with lipopolysaccharide or paclitaxel (Taxol).},
  author={Teruo Kirikae and Fumiko Kirikae and Yoichi Oghiso and Masayasu Nakano},
  journal={Infection and immunity},
  year={1996},
  volume={64 8},
  pages={3379-84}
}
Paclitaxel (Taxol), a yew-derived antimitotic agent which binds to microtubules, can mimic certain effects of lipopolysaccharide (LPS) on macrophages from LPS responder mouse strains. The production of nitric oxide (NO) by the peritoneal macrophages of LPS responder C3H/HeN mice stimulated with taxol or LPS was partially, but not completely, suppressed by microtubule-disrupting agents, such as colchicine, podophyllotoxin, vinblastine, and nocodazole, but not by lumicolchicine, an inactive… CONTINUE READING