Microtubule-depolymerizing kinesins.

  title={Microtubule-depolymerizing kinesins.},
  author={Claire E Walczak and Sophia Gayek and Ryoma Ohi},
  journal={Annual review of cell and developmental biology},
The microtubule (MT) cytoskeleton supports a broad range of cellular functions, from providing tracks for intracellular transport, to supporting movement of cilia and flagella, to segregating chromosomes in mitosis. These functions are facilitated by the organizational and dynamic plasticity of MT networks. An important class of enzymes that alters MT dynamics is the depolymerizing kinesin-like proteins, which use their catalytic activities to regulate MT end dynamics. In this review, we… CONTINUE READING

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