Microtubule-dependent retrograde transport of proteins into the ER in the presence of brefeldin A suggests an ER recycling pathway.

@article{LippincottSchwartz1990MicrotubuledependentRT,
  title={Microtubule-dependent retrograde transport of proteins into the ER in the presence of brefeldin A suggests an ER recycling pathway.},
  author={Jennifer Lippincott-Schwartz and Julie G Donaldson and Andreas Schweizer and Eric G. Berger and Hans Peter Hauri and Lydia C. Yuan and Richard D. Klausner},
  journal={Cell},
  year={1990},
  volume={60 5},
  pages={821-36}
}
Characteristics of brefeldin A (BFA)-induced redistribution of Golgi proteins into the endoplasmic reticulum (ER) and its relationship to an ER retrieval pathway were investigated. Retrograde movement of Golgi proteins into the ER occurred via long, tubulovesicular processes extending out of the Golgi along microtubules. Microtubule-disrupting agents (i.e., nocodazole), energy poisons, and reduced temperatures inhibited this pathway. In BFA-treated cells Golgi proteins appeared to cycle between… CONTINUE READING
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