Microtubule-dependent oligomerization of tau. Implications for physiological tau function and tauopathies.

@article{Makrides2003MicrotubuledependentOO,
  title={Microtubule-dependent oligomerization of tau. Implications for physiological tau function and tauopathies.},
  author={Victoria Makrides and Ting E Shen and Rajinder Bhatia and Bettye L. Smith and Julian Thimm and Ratneshwar Lal and Stuart C. Feinstein},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 35},
  pages={33298-304}
}
The accumulation of abnormal tau filaments is a pathological hallmark of many neurodegenerative diseases. In 1998, genetic analyses revealed a direct linkage between structural and regulatory mutations in the tau gene and the neurodegenerative disease, frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17). Importantly, the FTDP-17 phenotype is transmitted in a dominant rather than a recessive manner. However, the underlying molecular mechanisms causing disease remain… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Transport and diffusion of Tau protein in neurons

Cellular and Molecular Life Sciences • 2014
View 1 Excerpt

Similar Papers

Loading similar papers…