Microtubule-damaging agents enhance RASSF1A-induced cell death in lung cancer cell lines.

Abstract

BACKGROUND Tumor suppressor gene product RASSF1A has been reported to induce mitotic arrest and apoptosis through its interaction with microtubule and binding to the Ras effector NORE1. Despite this promising antitumor action of microtubule-targeted drugs, clinical studies demonstrated that paclitaxel (TXL) and vincristine (VCS) have differential antitumor… (More)
DOI: 10.1002/cncr.24113

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