Microtubule coils versus the surface membrane cytoskeleton in maintenance and restoration of platelet discoid shape.

@article{White1998MicrotubuleCV,
  title={Microtubule coils versus the surface membrane cytoskeleton in maintenance and restoration of platelet discoid shape.},
  author={James G. White and Gundu H. R. Rao},
  journal={The American journal of pathology},
  year={1998},
  volume={152 2},
  pages={597-609}
}
The discoid form of blood platelets is important to their function in hemostasis. Recent studies have suggested that the spectrin-rich surface membrane cytoskeleton and the cytoplasmic, actin-rich cytoskeleton are responsible for discoid shape, shape change, and recovery after activation or chilling. Earlier studies had suggested that circumferential coils of microtubules supported the disc shape of resting platelets and that their repositioning or reassembly restored disc shape after exposure… CONTINUE READING
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