Microtubule bundling by tau proteins in vivo: analysis of functional domains.

@article{Kanai1992MicrotubuleBB,
  title={Microtubule bundling by tau proteins in vivo: analysis of functional domains.},
  author={Yae Kanai and Ju Chen and Nobutaka Hirokawa},
  journal={The EMBO journal},
  year={1992},
  volume={11 11},
  pages={
          3953-61
        }
}
Tau varies both in the N-terminal region (three types) and in the C-terminal repeated microtubule binding domain (two types), generating six isoforms through alternative splicing. To understand the differences between the isoforms and to determine which domains are important for microtubule bundling, we performed transfection studies on fibroblasts using tau isoforms and deletion mutants to quantify their ability to bundle microtubules. By comparing the isoforms, we found that a longer N… CONTINUE READING

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